19-20 – November 2009 – Advanced Strategies for the Expression of Protein and Protein Complexes in Yeast - Venue: Barcelona


smallpcubeTransnational Access to Protein production and crystallisation screening platforms in the Division of Structural Biology, University of Oxford.

The inspiration behind a new EU Framework 7 programme aims to bring state-of-the-art protein preparation techniques to structural biologists across Europe. P-cube smallpcube provides funding to enable research groups to access any of the technology platforms for the benefit of their research. Funding covers all research materials for the access visit and residential accommodation for the duration of the visit. Travel should be funded independently, but some contribution may be made from P- smallpcube funds.

Access visits are eligible for P3smallpcube funding only from outside the national boundaries of the facilities sought (e.g. UK researchers cannot apply for P3 funding to use platforms in Oxford).

Access will be granted based on the scientific case as set out in the proposal form.

For details of P3smallpcube access platforms available and proposal forms, register at Access is available NOW.

A post-doctoral position is available for two years at IGBMC (Strasbourg) to study the structure of transcription complexes.

Adobe PDF DocumentPostDocPosition.pdf

Front coverXu, Y., Colletier, J.-P., Weik, M., Jiang, H., Moult, J., Silman, I. & Sussman, J.L. (2008). “Flexibility of Aromatic Residues in the Active-Site Gorge of Acetylcholinesterase: X-ray versus Molecular Dynamics” Biophys J 95, 2500-2511.
View Abstract

Proteopedia - a scientific 'wiki' bridging the rift between three-dimensional structure and function of biomacromoleculesprotopedia
Eran Hodis, Jaime Prilusky, Eric Martz, Israel Silman, John Moult, Joel L Sussman
Proteopedia is an interactive wiki-style web resource that presents 3D structural and functional information in a user-friendly manner and allows real-time community annotation.
Adobe PDF DocumentView pdf

Press release of Weizmann/PNAS paper available at

SPINE2 members should, where practicable, contribute protein structure information to CAPRI, see:
and/or CASP8, see:
The aim is to deposit the coordinates of reasonably simple structures as validation tools in each of these experiments. Rolf Boelens will keep a track of SPINE2 protein coordinates submitted to CAPRI and Joel Sussman will track those submitted to CASP8.

Spine 2 First year Report

For EC funded Transitional Access to BioNMR Infrastructures please visit the web site:

About SPINE2-Complexes

SPINE2-COMPLEXES is the second phase of a major protein structure initiative as part of the European Commission funded Framework 6 Research and Technological Development Programme. The full title of the project is "From Receptor to Gene: Structures of complexes from signalling pathways linking immunology, neurobiology and cancer". It is a multi-European institutional consortium with participating centres in 9 European countries and Israel and is coordinated by Professor David Stuart at the University of Oxford, UK.

The first phase of the protein structure initiative was the Framework 5 project "Structural Proteomics IN Europe" (SPINE) which spanned October 2002 - March 2006 and was also coordinated from Oxford. SPINE developed a pipeline procedure for protein structure determination, concentrating on protein structures of important human proteins, pathogens and proteins involved in human diseases and disorders. The project produced 308 novel protein structures and a further 61 derivative structures. SPINE also developed European standards in protein crystal handling for X-ray crystallography. These developments will now be used to tackle protein complexes involved in a number of signalling pathways involved in human health and disease.

Read more about SPINE2 here...

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ALL publications resulting from SPINE2 funding should correctly acknowledge EC support as follows: "This work was supported by European Commission funding through the SPINE2–COMPLEXES project LSHG–CT–2006–031220."


Esfri Instruct

Instruct project officially Commenced 1st April 2008

Spine2-complexes has developed significant links with FP7 INFRA-2007-2.2.1 An integrated Structural Biology infrastructure for Europe.



Spine 2-Complexes co-sponsors training programs in structural proteomics with TEACH-SG.