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Partner: Dr. Beata Vertessy
Deputy: Dr. Eniko Takacs
The Biological Research Center has been awarded the "Centre of Excellence" qualification from the European Union, as recognition for its excellent personnel and research activities. The Genome Metabolism and Repair Laboratory, is mainly interested in the molecular mechanisms of action of biological macromolecular systems involved in genome manipulations, in vitro, in situ and in vivo. The group has recently developed a complex test system, combining bacterial expression techniques with spectroscopic, enzyme kinetic, chromatographic and crystallographic approaches for detailed studies of protein structure-function relationships. Current research focuses on macromolecular conjugates within apoptotic and DNA repair pathways.
The leader of the research group, Dr. Vertessy, acquired expertise in varied methods in cell, molecular and structural biology during her work at the Institute of Enzymology and multiple short and long-term research stays in the USA, Sweden, Denmark, The Netherlands, and Germany (Alexander von Humboldt Fellow). She was recently named a Howard Hughes International Scholar, from the prestigious Howard Hughes Medical Institutes, USA. The group is involved in several collaborations within the EU (including a STREP project) and with the USA.
The Budapest group presents expertise in highly sensitive techniques for the production and study of biological macromolecular conjugates, including genetic engineering, cell cultivation, spectroscopy (UV/VIS absorbance, circular dichroism, fluorescence), microcalorimetry (differential scanning and isothermal titration), enzyme kinetics, protein crystallisation, structural modelling.
SPINE2-COMPLEXES 031220 is funded by the European Commission FP
