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Partner: Professor Maria-Armenia Carrondo
Deputy: Dr. Colin McVey
The Macromolecular Crystallography Laboratory at ITQB has contributed to the elucidation of the structures of metalloproteins involved in electron transfer processes, from single to multiheme cytochromes, iron-sulfur and iron storage proteins and several other metalloenzymes. Further projects involve a ribonuclease, RNase II, involved in the degradation of mRNAs, a lactase required for the assembly of the Bacillus subtilis endospore coat and proteins from the pathogenic bacteria Klebsiella pneumonia.
Technologies used include i) application of Pichia pastoris for expression of proteins involved in innate immunity ii) nano-drop crystallization screening iii) anaerobic crystallizations with oxygen controlled pressure (< 0.1 ppm), iv) nano-drop full spectrum UV/VIS spectrophotometry) and microspectrophotometer for UV/VIS absorption spectra from crystals.
SPINE2-COMPLEXES 031220 is funded by the European Commission FP
