Targets

WP1.1: Complexes in the ubiquitin signalling pathway

Ubiquitination
De-ubiquitination
Proteasome regulation

WP1.2: Cell life, death and integrity

Cell cycle (including ankyrin repeat protein complexes)
Apoptotic pathways (p53-dependent and p53-independent)
Control of cell integrity (e.g Lon type protease)

WP1.3: Complexes in development and synaptic signalling

Development and synaptic signalling assemblies
Protein complexes involving neuronal proteins dependent on copper

WP1.4: Protein kinases

Signalling and regulatory complexes involving protein kinases

WP1.5: Protein phosphatases

Protein phosphatases in regulatory cell pathways

WP1.6: Receptors/activators associated with transcription complexes

Nuclear receptor and transcription factor assemblies
Chromatin remodelling motors

WP1.7: Innate immune system

Complexes involved in pathogen recognition and subsequent signalling (including TLRs, NOD/NALP proteins, TIR domains, dectin)

WP1.8: Adaptive immune system

Cell surface receptors and recognition complexes (including MHC, TCR, NK receptor families)

WP1.9: Viral subversion of cellular signalling and immune modulation

Proteins modulating host responses (including those from EBV and poxviruses)
Proteins involved in host interactions such as receptor binding and fusion